MEDizzy - Gastrin gene knockout (GAS-KO) mice do not produce

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Gastrointestinal System

Gastrin gene knockout (GAS-KO) mice do not produce gastrin-17 (“little gastrin”) in response to food. As a direct consequence, which of the following substances will most likely be diminished in these animals?

ExplanationThe 17-amino-acid-long gastrin-17 (G17) is the classical gastrin that is released by antral G cells, in order to stimulate hydrochloric acid secretion from parietal cells directly and indirectly. It is also called little gastrin to distinguish it from the 34 aminoacid-form (G34, or big gastrin), which is more frequently released by duodenal rather than gastric cells.