MEDizzy - A client who has been receiving Urokinase (uPA) for deep

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A client who has been receiving Urokinase (uPA) for deep vein thrombosis is noted to have dark brown urine in the urine collection bag. Which action should the nurse take immediately?

ExplanationUrokinase is a thrombolytic agent used in the treatment of deep vein thrombosis, pulmonary embolus, or myocardial infarction. The presence of dark brown or rust-colored urine suggests bleeding. The nurse should withhold the medication, call the doctor immediately, and prepare to administer Amicar. Answer A is incorrect because vitamin K is not the antidote for urokinase. Answers B and C are incorrect because they do not address the adverse problem of bleeding.