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USMLE
Multisystem Processes
Which of the following describes the state of nitrogen balance for a normal, healthy 35-year-old person who consumes a diet that provides 75 g of protein and has a total nitrogen loss of 12 grams?
Explanation
ExplanationThe protein input can be converted to the nitrogen input by using the conversion factor of 6.25 g amino acids/g nitrogen. Hence, 75 grams of consumed protein/6.25 (g protein/g nitrogen) = 12 grams of nitrogen intake. Twelve grams of nitrogen intake minus 12 g of nitrogen loss equals a zero nitrogen balance. Note that the non-urea sources of nitrogen loss (typically a constant of 4 g) is included in the “total” nitrogen loss. (A) Nitrogen loss would have to be greater than the nitrogen intake to have a negative nitrogen balance. (B) Nitrogen loss would have to be less than the nitrogen intake to have a positive nitrogen balance. (D) The nitrogen balance can be calculated. It is the traditional method of determining dietary protein requirements of certain populations or individuals.
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