Which of the following is true regarding opioid-induced constipation?
ExplanationConstipation is the most frequent side effect of opioid therapy. Tolerance does not develop to this side effect. Therefore, as the dose of opioid increases, so does the potential for constipation. Frank bowel obstruction, biliary spasm, and ileus have occurred with opioid use. It is crucial to place patients on an active bowel regimen that includes laxatives, stool softeners, adequate fluids and exercise, and cathartics as needed to prevent the severe constipation that can occur with opioid use.
