Pain occurs when and where there is occlusion of small blood vessels by sickled erythrocytes, usually small bones of the extremities in smaller children and abdomen, chest, long bones, and lower back in older children

Tricyclic antidepressants are recommended for analgesia during the acute phase of a vasoocclusive crisis

Use of opioids is indicated in patients with severe pain

Painful crisis can be triggered by hypoxemia, cold, infection, and hypovolemia

Which of the following is false regarding sickle cell anemia in children?