Family history is the strongest single factor for developing major depressive disorder (MDD) and comorbid disorders are frequently encountered. Of the following, the MOST likely disorder that is associated with MDD is
ExplanationDysthymic disorder and anxiety disorders (prevalence 30% and 80%, respectively), substance abuse (20% to 30%), and disruptive behavior disorders (10% to 20%) are frequent comorbid disorders in depressed children and adolescents. Twenty percent of patients diagnosed with depression develop bipolar disorder (BD).