All of the following genetic mutations are associated with an increased risk of deep venous thrombosis EXCEPT:
ExplanationVenous thrombosis occurs through activation of the coagulation cascade primarily through the exposure to tissue factors, and the genetic factors that contribute to a predisposition to venous thrombosis typically are those polymorphisms affecting procoagulant or fibrinolytic pathways. In contrast, arterial thrombosis occurs in the setting of platelet activation, and the genetic predisposition for arterial thrombosis includes mutations that affect platelet receptors or redox enzymes. The most common inherited risk factors for venous thrombosis are the factor V Leiden mutation and the prothrombin 20210 mutation. Other mutations predisposing an individual to venous thrombosis include inherited deficiency of protein C or S and mutations of fibrinogen, tissue plasminogen activator, thrombomodulin, or plasminogen activator inhibitor. The glycoprotein Ib platelet receptor mutation would increase the risk of arterial, but not venous, thrombosis.
