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USMLE
The Body Fluids and Kidneys (I)
Given the following measurements, calculate the filtration fraction: Glomerular capillary hydrostatic pressure (PG): 70 mmHg Bowman’s space hydrostatic pressure (PB): 20 mm Hg Colloid osmotic pressure in the glomerular capillaries (πG): 35 mm Hg Glomerular capillary filtration coefficient (Kf): 10 ml/min/mm Hg Renal plasma flow: 428 ml/min
Explanation
ExplanationFiltration fraction (FF) = GFR ÷ Renal plasma flow (RPF). GFR = Kf × (PG − PB − πG) = 10 × (70 − 20 − 35) = 150 ml/min FF = 150 ml/min ÷ 428 ml/min = 0.35
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