MEDizzy - Questions 11–13 Match the cellular location for each of the

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The Cell and General Physiology

Questions 11–13 Match the cellular location for each of the steps involved in the synthesis and packaging of a secreted protein listed below with the correct term from the list below. Initiation of translation

ExplanationInitiation of translation, whether of a cytosolic protein, a membrane-bound protein, or a secreted protein, occurs in the cytosol and involves a common pool of ribosomes. Only after the appearance of the N-terminus of the polypeptide is it identified as a protein destined for secretion. At this point, the ribosome attaches to the cytosolic surface of the rough endoplasmic reticulum. Translation continues, and the new polypeptide is extruded into the matrix of the endoplasmic reticulum.