MEDizzy - A 42-year-old man with heme occult-positive stools and a

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Infection causing diseases 2

A 42-year-old man with heme occult-positive stools and a history of epigastric pain is found to have a duodenal ulcer that is biopsy-proven positive for H pylori. All of the following are efective eradication regimens EXCEPT:

ExplanationIn vitro, H pylori is susceptible to a wide variety of antibiotics. However, monotherapy is no longer recommended because of inadequate antibiotic delivery to the colonization niche and the development of resistance. All current regimens include either a proton pump inhibitor (omeprazole or equivalent), H2 blocker (ranitidine or equivalent), and/or bismuth. Regimens including quinolones may not be advisable because of common resistance and the risk of developing C difcile colitis. Current regimens have an eradication rate of 75%– 80%.