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USMLE
Anemia & Hemorrhagic Disorders
Questions 7 and 8: A 23-year-old African-American man with a history since early childhood of severe anemia requiring many transfusions has nonhealing leg ulcers and recurrent periods of abdominal and chest pain. The spleen of the patient would be expected to be
Explanation
ExplanationRepeated episodes of splenic infarction followed by fibrotic healing lead to a fibrotic, shrunken spleen (autosplenectomy) in adult patients with sickle cell anemia. The spleen is enlarged and congested in children with sickle cell anemia
USMLE
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