MEDizzy - Questions 7 and 8: A 23-year-old African-American man with a

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Anemia & Hemorrhagic Disorders

Questions 7 and 8: A 23-year-old African-American man with a history since early childhood of severe anemia requiring many transfusions has nonhealing leg ulcers and recurrent periods of abdominal and chest pain. These signs and symptoms are most likely to be associated with which of the following laboratory abnormalities?

ExplanationSickle cell anemia is the most common hereditary anemia of persons of African lineage. Leg ulcers and recurring painful crises are characteristic. In sickle cell anemia, in contrast to sickle cell trait, sickle cells are often seen on the peripheral blood smear.