A negative free-water clearance (−CH2O) will occur in a person who
ExplanationA person who produces hyperosmotic urine (1000 mOsm/L) will have a negative free-water clearance (−CH2O) [CH2O = V – Cosm]. All of the others will have a positive CH2O because they are producing hyposmotic urine as a result of the suppression of antidiuretic hormone (ADH) by water drinking, central diabetes insipidus, or nephrogenic diabetes insipidus.
