MEDizzy - A 34-year-old man is seen over multiple visits for

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Comprehensive Questions

A 34-year-old man is seen over multiple visits for complaints of “ulcers,” despite the use of ranitidine. Further studies, finding elevated levels of gastrin and evidence of ulcers involving the jejunum, suggest a diagnosis of Zollinger-Ellison syndrome. Which of the following agents would be most useful in the management of this patient?

ExplanationLansoprazole is an H1/K1-ATPase proton pump inhibitor useful in the treatment of patients who have failed histamine H2-blocker therapy and patients with Zollinger-Ellison syndrome. Famotidine is a histamine H2-blocker. Misoprostol is used to prevent ulcers in patients taking nonsteroidal anti-inflammatory drugs (NSAIDs). Prop- antheline is a cholinergic agent used in conjunction with other agents, and rarely alone. Ulcers associated with Helicobacter pylori can be treated with Pepto Bismol.