Which of the following statements is correct regarding wound healing and persistent local tissue hypoxia?
ExplanationC. Oxygen deficiency of the tissues is the most common cause of poor wound healing. Proper tissue oxygenation requires sufficient inspired PO2 , transfer of oxygen to hemoglobin, ample hemoglobin for transport, and adequate vascularity of the tissues. Most healing problems associated with diabetes mellitus, irradiation, small vessel atherosclerosis, and chronic infection are a result of a faulty oxygen delivery system. Transiently low wound tissue oxygen levels stimulates cell migration, growth factor release, and collagenase production. Similarly, high lactate levels stimulate the macrophage to produce angiogenesis factors. Fibroblasts are oxygen sensitive and are inhibited by low tissue oxygen tension. Collagen synthesis is also inhibited by low tissue oxygen
