While doing your medicine clerkship, you hear an announcement that a CPR team should immediately report to the room of one of the patients. Being an inquisitive student, you decide to observe how the code team manages this unfortunate patient’s CPR. The rhythm monitor displays ventricular fibrillation that is quickly converted to atrial fibrillation with a rapid ventricular response. The senior resident orders amiodarone to be administered to this patient. Since you forgot how this agent works, you ask one of the residents to explain how this medication works. The resident replies that he is busy, but tells you it is a class III antiarrhythmic agent. What is the mechanism of action of this agent?
ExplanationAmiodarone is a class III antiarrhythmic agent that interferes with out- ward potassium current. β-Receptor antagonists are considered class II antiarrhythmics. Class I antiarrhythmics block fast sodium channels. Amiodarone prolongs the effective refractory period. It has a rather long half-life, up to 100 days.