MEDizzy - In an experiment, bacteria are introduced into a perfused

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Inflammation and Repair

In an experiment, bacteria are introduced into a perfused tissue preparation. Leukocytes leave the vasculature and migrate to the site of bacterial inoculation. The movement of these leukocytes is most likely to be mediated by which of the following substances?

ExplanationChemokines include many molecules that are chemotactic for neutrophils, eosinophils, lymphocytes, monocytes, and basophils. Bradykinin causes pain and increased vascular permeability. Complement C3a causes increased vascular permeability by releasing histamine from mast cells. Histamine causes vascular leakage.