MEDizzy - Statins are the commonest agents used to manage

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Diabetes and Lipid Metabolism

Statins are the commonest agents used to manage dyslipidaemia in patients with diabetes although these have been associated with an increase risk of development of diabetes. Which one of the following statins has been associated with a reduction in risk of development of DM?

ExplanationB. Statin use has been linked with an increased risk of the development of diabetes. A metaanalysis of five trials (PROVE-IT, A to Z, TNT, IDEAL, and SEARCH), involving more than 32,000 patients without diabetes, compared the effects of high dose statins with conventional dose statins with a 12% increased risk of developing diabetes in the former compared with the later. In another meta-analysis of 13 statin trials, 4278 individuals out of a total of 91,140 participants, developed diabetes during a mean period of 4 years, equating to a 9% increased risk for development of diabetes while on statin therapy. On the contrary, the sub-group analysis results of the LIVES trial (Livalo Effectiveness and Safety) have shown improvement in glucose homeostasis, with an increase in HDL-cholesterol levels with pitavastatin use.