An 18-year-old boy was incidentally detected to have high fasting blood glucose readings on a routine medical check-up for army recruitment. He had no history of osmotic symptoms. He had a strong family history of diabetes with three of his first cousins and two of the paternal uncles having medication-treated diabetes. On examination, he had BMI of 23 kg/m2 with normal general physical and systemic examination. His repeat blood tests confirmed elevated fasting glucose (7–9 mmol/L), although the post-prandial blood glucose was within normal range. Which one of the following is the most appropriate management approach for his elevated fasting blood glucose levels?
ExplanationD. Glucokinase mutation is associated with altered glucose sensing in the pancreatic β-cells, leading to mild hyperglycaemia with elevated fasting blood glucose readings. This can be managed with diet and most individuals do not develop any microvascular complication on a long-term basis.