MEDizzy - To facilitate or ease learning about the autonomic nervous

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Pharmacology of peripheral nervous system 2

To facilitate or ease learning about the autonomic nervous system (or most other things), it’s sometimes helpful to identify a generally applicable “rule” and then learn the one or two main exceptions to it. So, sympathetic innervation of which of the following structures is the exception to the general rule that “all postganglionic sympathetic nerves are adrenergic?”

ExplanationTubocurarine, arguably the prototypic nondepolarizing skeletal neuromuscular blocker (competitive antagonist of the effects of ACh on skeletal muscle nicotinic receptors), differs from most of the other nondepolarizing neuromuscular blockers (including pancuronium; c) because it triggers histamine release. It exerts a “direct” degranulating effect on mast cells, not one involving the activation of mast cell antibodies. This histamine-releasing effect is not clinically significant for patients who do not have asthma, but for many who do, the bronchoconstriction can be intense and problematic (even though the patiTubocurarine, arguably the prototypic nondepolarizing skeletal neuromuscular blocker (competitive antagonist of the effects of ACh on skeletal muscle nicotinic receptors), differs from most of the other nondepolarizing neuromuscular blockers (including pancuronium; c) because it triggers histamine release. It exerts a “direct” degranulating effect on mast cells, not one involving the activation of mast cell antibodies. This histamine-releasing effect is not clinically significant for patients who do not have asthma, but for many who do, the bronchoconstriction can be intense and problematic (even though the patient is intubated). In the absence of (released) histamine, curare and the other neuromuscular are intubated). In the absence of (released) histamine, curare and the other neuromuscular