MEDizzy
MEDizzy
USMLE
Nephrology and urology
A 55 year old man with significant cardiovascular disease and diabetes has acute kidney injury in the context of a viral illness. He was at a social gathering where he consumed alcohol and woke the next morning unwell. He had fever, aches and pains, headache and felt thirsty. He takes atorvastatin, lansoprazole, amlodipine, bisoprolol, warfarin, digoxin regularly. He passed a small amount of dark urine. His creatinine is 190 μmol/L (2.15 mg/dL), potassium 6.8 mmol/L, corrected calcium 1.97 mmol/L (7.90 mg/dL), international normalised ratio (INR) 2.0. Urine dipstick shows haematuria but no proteinuria. Direct urinalysis revealed no cells or casts. What is the likely cause of his kidney injury?
Explanation
ExplanationRhabdomyolysis is the most likely diagnosis given the dark urine and risk factors, including a statin, viral illness and alcohol use. Many cases will have several risk factors and rhabdomyolysis may occur after being on a statin for some time. The dipstick ‘haematuria’ without red cells being visible is due to urine myoglobin. Intracellular ions (potassium, phosphate) tend to be particularly high with rhabdomyolysis and calcium may be low (precipitates with phosphate).
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