A 35-year-old woman presents to her primary
care physician with complaints of progressive
weakness over the past month. She states that
she has noticed an increasing amount of difficulty associated with getting out of chairs,
climbing stairs, brushing her hair, and lifting
her 3-year-old son out of his playpen, an activity that she was able to do without difficulty
prior to the onset of her weakness. She admits
to missing 3 days of work approximately 6
weeks ago due to “a bad cold.” Physical examination is remarkable for symmetric proximal
muscle weakness. Several tests are ordered to
establish a diagnosis. Which of the following
most strongly supports a diagnosis of polymyositis?