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USMLE
Microbiology
Oncogenic viruses act through a variety of mechanisms. Some introduce oncogenes directly into host cells, while others force cells to repeatedly undergo cycles of proliferation that eventually become unregulated. Still others introduce oncogenic potential by manipulating chromosomal structure through deletions or translocations. Which of the following viruses causes neoplasia by inactivating tumor suppressor genes such as p53 and Rb?
Explanation
ExplanationD. Human papillomavirus (HPV) causes carcinoma (usually cervical) by inactivating tumor suppressor genes such as p53 and Rb through the actions of viral proteins E6 and E7, respectively.
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