Drugs for Degenerative Disorders of the Central Nervous System
A 74-year-old man who had been suffering from Parkinson disease for 4 years complained of a purplish red mottling of the skin that began on his thighs and spread to his lower legs. The eruption appeared 2 weeks after a drug was added to his therapeutic regimen. A diagnosis of livedo reticularis was made. Which of the following drugs most likely caused this skin eruption?
ExplanationD Livedo reticularis can occur in up to 80% of patients taking amantadine and usually clears within 1 month after drug withdrawal. The disorder is believed to be caused by local release of catecholamines that can cause vasoconstriction.