MEDizzy - A 68-year-old patient was recently diagnosed with Parkinson

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Drugs for Degenerative Disorders of the Central Nervous System

A 68-year-old patient was recently diagnosed with Parkinson disease. His medical history included benign prostatic hyperplasia for 2 years and chronic constipation for 5 years. Which of the following antiparkinson drugs would be contraindicated for this patient?

ExplanationB Anticholinergic drugs such as benztropine are sometimes used in Parkinson disease but are contraindicated in case of prostatic hypertrophy, because they decrease the contraction of the detrusor muscle, and in the case of chronic constipation, as they decrease intestinal peristalsis. In addition, they are relatively contraindicated in elderly individuals (see the patient’s age) because the risk of their central adverse effects increases with age.