MEDizzy - A 59-year-old man with a long history of chronic obstructive

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Drugs for Bronchospastic Disorders

A 59-year-old man with a long history of chronic obstructive pulmonary disease recently had theophylline added to his therapeutic regimen. Which of the following actions most likely occurred during the first days of the new therapy?

ExplanationMethylxanthines stimulate gastric secretion, which can explain the abdominal discomfort that frequently occurs after the administration of theophylline. The effect on gastric secretion is most likely due to theophylline-induced inhibition of phosphodiesterase, which in turn increases intracellular cyclic adenosine monophosphate (cAMP), thus causing an activation of H+/K+ ATPase.