MEDizzy - A 34-year-old woman was at the dentist for an endodontic

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Adrenergic drugs

A 34-year-old woman was at the dentist for an endodontic procedure. Before starting the procedure, the dentist inject a solution of lidocaine plus epinephrine near the tooth in order to provide local anesthesia. The epinephrine-induced increased duration of the lidocaine effect was most likely mediated by the activation of which of the following adrenoceptors?

Explanationc Epinephrine is often used together with local anesthetics to prolong the action of the anesthetic. This increased duration is due to the epinephrine-induced vasoconstriction mediated by α1 receptor activation), which localizes the anesthetic at the desired site, thus slowing down its systemic distribution