MEDizzy - A 49-year-old Asian woman recently diagnosed with

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Antimycobacterial Drugs

A 49-year-old Asian woman recently diagnosed with tuberculosis started an appropriate multidrug therapy. Which of the drugs she was taking is inactivated by hepatic acetylation, the rate of which depends on genetic background?

ExplanationIsoniazid is metabolized by hepatic acetylation, which is under genetic control. Patients may be fast acetylators (mainly among people of Asian origin) or slow acetylators (mainly among people of European and African origin). Fast acetylators require higher dosage than slow acetylators to obtain equivalent therapeutic effects.