MEDizzy
MEDizzy
USMLE
metabolism - Set 17
In an experiment you mutate the consensus sequence at the -10 box. You observe the rate of transcription reduces. Now you make complementary mutation to the sigma factor. What will you observe?
Explanation
ExplanationComplementary mutation in sigma factor helps to restore its -10 box recognition capacity which restores normal transcription rate. However, to improve the rate further both the -10 and -35 box sequences should be made more like the consensus.
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