Inactive miRNA undergoes how many cleavages before incorporation into the RISC complex?
ExplanationThe process of formation of the active RNA complex needs the cleavage miRNA. The miRNA gene is transcribed into pri-miRNA that folds into a hairpin structure. Nuclear enzyme Drosha cleaves pri-miRNA into pre-miRNA which is exported out from the nucleus. In the cytosol dicer cleaves the pre-miRNA into miRNA. This miRNA is now incorporated into RISC.
