Medicalcortex
Medicalcortex
in General
Purpura fulminans
Purpura fulminans
Purpura fulminans also known as "Purpura gangrenosa" is an acute, often fatal, thrombotic disorder which manifests as blood spots, bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation. Its caused by protein C deficieny which is usually congenital and rarely in sepsis and infections Activated protein C binds to endothelial protein C receptor and subsequently cleaves the endothelial cell protease activated receptor-1, not only altering coagulation profiles but down-regulating pro-inflammatory and pro-apoptotic mediators, up-regulation of anti-inflammatory and anti-apoptotic pathways and stabilization of the endothelial cell barrier functions. Systemic coagulation activation may lead to depletion of circulating coagulation factors and platelets, which subsequently lead to bleeding. The depletion of anticoagulant and anti-inflammatory proteins, in particular, protein C and its co-factor, protein S, may also promote thrombus formation, inhibit fibrinolysis and lead to further activation of the inflammatory pathways.
Ali Bassim
Ali Bassim
in Case Study
Rheumatoid arthritis for 20 years!
Rheumatoid arthritis for 20 years!
Can you name the signs of rheumatoid hand?
My iz♡
My iz♡
in General
Acute Otitis Media
Acute Otitis Media
Acute otitis media is a very common cause of ear pain in children with 60 - 80% of children with one episode by 1 year of age and 80 - 90% by two to three years of age. The incidence of AOM is in decline and may be related to the increased use of the pneumococcal conjugate vaccine. Acute otitis media requires BOTH diagnostic criteria:      Middle ear inflammationBudging of the tympanic membraneErythema of the tympanic membraneOtalgia     Middle ear effusionTympanic membrane opacityDecreased tympanic membrane mobilityAir-fluid levelsOtorrhea Risk factors for AOM: Age: 6 and 18 monthsFamily history (relative risk 2.63)Day care attendance (relative risk 1.59, 2.45 in different studies)No breastfeeding (relative risk 0.87) - likely due to increased bacterial nasopharyngeal colonization and immunologic protective factorsTobacco smoke (relative risk 1.48)Pacifier use (relative risk 1.24)Native Americans, Alaskan and Canadian Inuit children, and indigenous Australian childrenPoverty and household crowdingFall and winter Pathogenesis (usual):      Antecedent viral upper respiratory tract infection     Resultant inflammatory edema of the respiratory mucosa     Eustachian tube obstruction     Negative middle ear pressure with resultant buildup of middle ear secretions     Bacterial growth in the middle ear secretions resulting in suppurative infection
Yankila
Yankila
in Learning Materials
Vernix caseosa
Vernix caseosa
Vernix caseosa, also known as vernix, is the waxy or cheese-like white substance found coating the skin of newborn human babies. It is produced by dedicated cells and is thought to have some protective roles during fetal development and for a few hours after birth.
Allaa M. El-hawat
Allaa M. El-hawat
in General
Plz I need an answer with explanation for this question !!!
Nerve and Muscle Physiology
Nerve and Muscle Physiology
Yankila
Yankila
in Learning Materials
Myoma
Myoma
Subserous myoma and intramural myoma
Jeeviamonica Johnson
Jeeviamonica Johnson
in Discussion | 9 hours ago
Medicaltalks
Medicaltalks
in General
Leiomyomas of the uterus!!
Leiomyomas of the uterus!!
This is a hysterectomy done due to numerous large uterine fibroids! Uterine fibroids, also called leimyomas or myomas, are benign tumors that arise from the overgrowth of smooth muscle and connective tissue in the uterus. Fibroids are the most common benign gynecologic tumors. Symptoms vary depending on the size and number of fibroids; heavy and prolonged menstrual bleeding, pain and pressure in lower abdomen, constipations and urination controlling problems. The surgical treatment shown here, total hysterectomy, is done in rare cases where the fibroids are too huge and resist hormonal medical treatment. That is because all leiomyomas are tumors, so medical management has a limited role in the resolution or destruction of these lesions.
Hamza Aldhadha
Hamza Aldhadha
in Discussion | 11 hours ago
MEDizzy
MEDizzy
in General
Drop your answer in comments. It’s Time to End Tuberculosis!
Drop your answer in comments. It’s Time to End Tuberculosis!
Ketul Patel
Ketul Patel
in Learning Materials
Awesome mnemonic for cranial nerves and its type
Awesome mnemonic for cranial nerves and its type
Medshots
Medshots
in General
Nose ring removal went wrong!
Nose piercing is all fun, till you hit an artery while removing it! Which artery is injured here?
My iz♡
My iz♡
in General
Local Anesthetic Injection Techniques 
Local Anesthetic Injection Techniques 
Local Anesthetic Techniques -  The technique of local anesthetic administration is an important consideration in pediatric patient behavior guidance.3 Age-appropriate nonthreatening terminology, distraction, topical anesthetics, proper injection technique, and nitrous oxide/oxygen analgesia/anxiolysis can help the patient have a positive experience during adminis- tration of local anesthesia.3-5 In pediatric dentistry, theIntrapulpal Injection Deposition of local anesthetic directly into the pulp chamber of a pulpally involved tooth provides effective anesthesia fro pulpal extirpation and instrumentation zThe intrapulpal injection may be used on any tooth when difficulty in providing profound pain control exists z z techniques anesthesia Traumatic deposited. control* anesthesia.Advanced local anesthetic techniques include the Vazirani-Akinosi mandibular block, intraseptal injections, and pre-puncture technique for the C-CLAD.NEW! Coverage of dynamic and emerging topics include newer anesthetic agents, buffering of anesthetics, determination of drug dosages, armamentarium and syringe preparation, maxillary and mandibular injection techniques and �The improvements in techniques for local anesthesia are probably the most significant advances that have occurred in dental science. This paper provides an update on comparatively newer gadgets that are less commonly used to deliver local anesthetics. Keywords: Computer controlled local anesthesia delivery system (CCLAD), Intraosseous Injection delivery system, Local anesthesia delivery device
Andy Wells
Andy Wells
in Case Study
Kerion — A Boggy Lump
Kerion — A Boggy Lump
A 13-year-old girl presented with a slowly enlarging, painful swelling of the scalp that had first been noticed 3 weeks earlier. She had received several courses of empirical oral antibiotics for suspected bacterial folliculitis and cellulitis, without improvement. On examination, there was an erythematous, mildly tender, boggy swelling overlying her occiput (Panel A). The lesion was studded with pustules and had associated serosanguineous discharge and alopecia. A sample from the involved area was obtained, and a 10% potassium hydroxide preparation revealed fungal hyphae and confirmed the diagnosis of a kerion. A kerion is an inflammatory, dermatophytic, fungal infection of the scalp that is usually seen in children. It is characterized by a suppurative, tender swelling that is often associated with regional lymphadenopathy and can be mistaken for bacterial folliculitis. Kerion is most commonly caused by the zoophilic dermatophytes Trichophyton verrucosum and Trichophyton mentagrophytes. Treatment with oral griseofulvin is often used, although other antifungal agents may also be effective. A delay in diagnosis and treatment can result in scarring alopecia. This patient was treated with griseofulvin for 6 weeks and showed marked improvement, with regression of the lesion (Panel B). Shraddha Uprety, M.D. Ramesh Sharma, M.D. Tribhuvan University, Bharatpur, Nepal source: nejm.org
Nilay Kumar Kedia
Nilay Kumar Kedia
in Discussion | 20 hours ago
fatimaumairaa@gmail.com
fatimaumairaa@gmail.com
in Discussion | 18 hours ago
alien hand syndrome
i need info regarding alien hand syndrome
Medshots
Medshots
in General
Finally, a picture explaining the proper way of wearing the medical gloves.
Finally, a picture explaining the proper way of wearing the medical gloves.
My iz♡
My iz♡
in General
Surgical Treatment of Phrenic Nerve Injury
This video demonstrates the surgical techniques used to perform phrenic nerve reconstruction in a patient with hemidiaphragm paralysis due to phrenic nerve injury.
My iz♡
My iz♡
in General
Necrotizing
Necrotizing
Crohn's disease is a disease of the bowel, typically presenting with diarrhea, weight loss, and abdominal pain. Complications such as abscesses, fistulas, and strictures may require surgical intervention. We would like to report a patient with Crohn's disease who presented for the first time with left lower extremity necrotizing fasciitis. There are very few reports of necrotizing fasciitis in Crohn's disease as the initial 1. Introduction Crohn's disease is primarily a disease of the bowel, which typically presents with diarrhea, weight loss, and abdominal pain. It most commonly affects the distal ileum and colon. It is characterized by extensive fibrosis, strictures, and fistulas [1]. Complications such as abscesses, fistulas, and strictures may require surgical intervention. We would like to report a patient with Crohn's disease, who primarily presented with left lower extremity necrotizing fasciitis. There are very few reports of necrotizing fasciitis in Crohn's disease [2], none in which fasciitis was the primary presenting symptom. 2. Case report A 62 year old man presented to the Emergency Department with three weeks of left thigh edema, new onset erythema and excruciating pain to light touch. He had no known past medical history, was taking no medications, and was a heavy smoker. The patient was cachectic on general examination. He was tachycardic with elevated white cell count and erythrocyte sedimentation rate. A computed tomography (CT) scan was obtained which revealed extensive subcutaneous gas and fluid from the anterior superior iliac scpine to the iliopsoas, and circumferentially along all fascial planes. Additionally, a small fluid collection was seen along the left psoas muscle bed; no other fluid collections were noted radiographically. General Surgery was consulted and the patient was brought emergently to the operating room. The anterior and posterior compartments contained a significant amount of purulent, foul-smelling fluid, and the degree of necrosis necessitated hip disarticulation Surgical specimen after hip disarticulation. The anterior and posterior compartments contained a significant amount of purulent, foul-smelling fluid. Extensive necrosis was evident up to the level of the iliopsoas.
Dr. Grace
Dr. Grace
in Learning Materials
Radiology
Radiology
Page: 1 / 857
123857
Discussions
New Discussion
Start a new interesting discussion or ask other people to help you!
Success