What is cholestasis? Cholestasis, or cholestatic liver disease, is a condition where bile gets into the liver tissue and blood stream, causing liver damage and a variety of complications. Intra-hepatic cholestasis happens in the liver and is caused by liver cells, whereas extra-hepatic cholestasis happens outside the liver and is usually from an obstruction in the bile ducts. This video is brought to you by Osmosis. Along with providing open-access videos, Osmosis offers a comprehensive e-learning platform that connects med students with thousands of flashcards and quiz questions, depending on each student's needs. Ever wish information would just diffuse into your brain? Well, Osmosis helps make that possible—don't just study it, Osmose It! https://www.osmosis.org/ This video is licensed under a Creative Commons CC-BY-SA 4.0 international license, which means that you're free to share and adapt it so long as you follow the Attribution and ShareAlike terms and conditions.