Pemphigus vulgaris

It is an autoimmune disease that involves blistering and erosion of skin and mucous membrane. Exclusive in middle aged and old age group. Causes- In the case of pemphigus vulgaris, the immune system mistakenly produces antibodies against specific proteins in the skin and mucous membranes, known as desmogleins. These proteins form the glue that keeps skin cells attached and the skin intact. When desmogleins are attacked, skin cells separate from each other and fluid can collect between the layers of skin, forming blisters that do not heal. In some cases, these blisters can cover a large area of skin. Treatment- The most common first line therapy for pemphigus vulgaris is: Steroids (corticosteroids), such as prednisone. Steroids can help a person go into remission and stay in remission, however this must be balanced with the medical problems that can be caused by the long term use of steroids.