Nikki⚕️Hariover 6 years ago

SIGNS OF CHOLINERGIC CRISIS : *In Cholinergic crisis,there is INCREASED cholinergic activity. *It is due to acetylcholinesterase inactivity/insufficiency. *So,there is persistant depolarisation of muscle....causing muscle weakness ultimately leading to respiratory failure. S. I. G. N. S Mnemonic: D U M B E L L S 1. DIARRHOEA (& diaphoresis) and abdominal cramping 2. URINATION 3. MIOSIS (pin-point pupil) 4. BRADYCARDIA (muscarinic) and tachycardia(nicotinic) 5. EMESIS (nausea and vomiting) 6. LACRIMATION 7. LETHARGY 8. SALIVATION