Granulomatous inflammation is a type of chronic inflammation that helps the body to contain the spread of an infection. Granulomas are formed when immune cells(macrophages) attempt to wall off substances they perceive as foreign but are unable to eliminate. When certain infectious organisms are the causatives of the granuloma formation, the central zone of the granuloma undergoes necrosis because of hypoxia and free radical activity. The necrotic materials at the center have a cheesy white appearance. A caseating granuloma is a granuloma with such a center that has undergone caseous necrosis. Eg: In Tuberculosis Noncaseating granuloma refers to all granulomas that do not have a center that has undergone caseating necrosis. Noncaseating granuloma appears in conditions such as sarcoidosis, leprosy, and Crohn’s disease.
