Necrosis Localized area of cell death followed by degeneration of cell by hydrolytic enzymes from death cell. 1) cell digestion by lytic enzyme 2) protein denaturation Types of necrosis Colugative. Necrosis Eg: heart kidney spleen Due to ischemia Gross: pale firm swollen yellow color Micro: tomstones Liquefactional necrosis Eg. Brain abscess cavity Due to hydrolytic enzymes Gross. Soft liquid cyst wall Micro. Cystic wall with cell debris and inflammation reactions Caseous necrosis Eg. Center focii of tb Gross. Dry cheese yellow granullar soft Micro granulomatous inflammation reactions granullar debris Fat necrosis Eg pancreatic and traumatic Gross calcium soap yellow colour Micro. Cloudy chalk colour inflammation reactions Fribrinoid necrosis Eg auto immune disease
