Myelofibrosis progresses slowly, so you may not have symptoms for many years. About one-third of people don’t show symptoms during the disorder’s early stages. When they arise, the most common symptoms of myelofibrosis are severe fatigue (resulting from anemia) and an enlarged spleen. Symptoms may include: Fatigue. Fever. Itching. Pale skin. Weight loss. Night sweats. Bone or joint pain. Frequent infections. Enlarged spleen or liver. Unexplained blood clots. Abnormal bleeding or bruising. Enlarged veins in your stomach and esophagus. (These veins may rupture and cause bleeding.)