You may not have any symptoms of pancytopenia, or you may have symptoms associated with anemia, leukopenia, or thrombocytopenia. Anemia. Symptoms of anemia can include: Headaches Cold hands and feet Tiredness Weakness Pale or yellowish skin Shortness of breath Irregular heartbeat Chest pain Dizziness or lightheadedness Leukopenia. You may not have any symptoms with leukopenia. If you do, they might include: Infection Chills Fever over 100.4 F Sweating Thrombocytopenia. As thrombocytopenia affects your blood's ability to clot, its symptoms may include: Bruising easily or a lot Prolonged bleeding from cuts Tiredness Enlarged spleen Nosebleeds Bleeding gums Blood in your urine or stool Heavy menstrual flow