Almost anyone can have dandruff, but certain factors can make you more susceptible: Age. Dandruff usually begins in young adulthood and continues through middle age. That doesn't mean older adults don't get dandruff. For some people, the problem can be lifelong. Being male. Dandruff is more prevalent in males than in females. Certain illnesses. Parkinson's disease and other diseases that affect the nervous system also seem to increase risk of dandruff. So does having HIV or a weakened immune system.