Cocaine related Angina

Cocaine has sympathomimetic effects that induce tachycardia and hypertension, resulting in an increased myocardial-oxygen demand. When this demand exceeds the supply, myocardial ischemia occurs. But unlike the conventional angina, beta-blockers are contraindicated in cocaine-angina, as they increase the effect of alpha-receptors and worsen hypertension and chest pain. Chest pain in cocaine intoxication is treated with benzodiazepines.