Vijay Kumar7 months ago

Adenocarcinoma of Esophagus

Esophageal adenocarcinoma results from the chronic exposure of the squamous epithelium to gastric contents. This results in cardiac metaplasia, which is the first necessary step in the gastroesophageal reflux disease (GERD) → adenocarcinoma sequence. Esophageal adenocarcinomas are most commonly seen in patients with visible columnar-lined esophagus (CLE) that is caused by severe reflux associated with abdominal LES damage >25 mm. They occur only when the cardiac epithelium undergoes intestinal metaplasia, which is the target epithelium for carcinogenesis.