Recently, a comprehensive DNA Methylation Aging Clocks platform, as a promising aging research technology combined with robust biologic strategies, was developed to help researchers in achieving scalable targeted methylation sequencing, high-performance DNA methylation biomarker analysis, as well as accurate age prediction of many species. DNA Methylation Aging Clocks technology is designed based on quantifying the epigenetic DNA methylation levels, measuring the accumulation of methyl groups in one's DNA molecules. This unique high-throughput sequencing allows for low-cost and scalable targeted methylation sequencing, enabling high-performance age-related DNA methylation biomarker analysis and the construction of epigenetic clocks to accurately predict age within species. Moreover, a detailed assessment of DNA methylation clocks can bring valuable insights into the aging process as well as the research of age-associated diseases.