There are many treatment options for sinusitis, depending on your symptoms and how long you’ve had them. You can treat a sinus infection at home with: Decongestants. Over-the-counter (OTC) cold and allergy medications. Nasal saline rinses. Drinking plenty of fluids. If symptoms of sinusitis don’t improve after 10 days, a provider may prescribe: Antibiotics. Oral or topical decongestants. Prescription intranasal steroid sprays. (Don’t use nonprescription sprays or drops for longer than three to five days — they may actually increase congestion.) Providers treat chronic sinusitis by focusing on the underlying condition. Treatments can include: Intranasal steroid sprays. Topical antihistamine sprays or oral pills. Leukotriene antagonists, like montelukast. Surgery to treat structural issues, polyps or fungal infections.