Whole-body magnetic resonance imaging (WB-MRI) has been available for some time, but only recently it has become an efficient method for total body screening from head to toes. In clinical practice, WB-MRI is increasingly being used in the diagnosis of a variety of diseases, including lymphomas, multiple myeloma, systemic musculoskeletal diseases, and also systemic diseases like diabetes and atherosclerosis. Furthermore, WB-MRI is very useful in children with malignant diseases (and other pathologies) due to the use of non ionising radiation. Improvements of the software and hardware, multiplanar imaging capabilities, high contrast resolution, anatomical and functional imaging make MRI a great alternative for whole body screening within clinically acceptable acquisition times