Iqra11 months ago

Causes of fanconi anemia

FA is a genetic disorder caused by inherited mutations (discrete changes in genetic code) in a group of genes (genetic blueprints) for proteins. We have about 20 FA genes, but not all of them are affected when genes mutate. FA genes protect us from DNA damage that happens throughout life. When FA genes mutate, proteins that typically repair routine DNA damage don’t work properly and can’t fix damaged DNA. Here’s what happens: The DNA damage continues to spread, causing abnormal cell growth or cell death. Abnormal cell death can cause physical abnormalities linked to FA, as well as reduce the amount of blood cells our bodies need to function. Abnormal cell growth can lead to acute myeloid leukemia or other types of cancer.