Healthcare providers will determine why your sclera is blue before deciding on specific treatments. Knowing why your sclera is blue is the only way providers know how to treat it. A blue sclera may be a symptom of an underlying condition. For example, people with inherited conditions such as Marfan syndrome or osteogenesis imperfecta may develop a blue sclera. In those cases, providers will emphasize treatment for the underlying condition. Those treatments may help with blue sclera. Treatments will vary depending on the disorder causing the blue sclera.