Causes of blue sclera include genetic conditions, such as: Osteogenesis imperfecta (OI, brittle bone disease). Marfan syndrome, a connective tissue disease. Ehlers-Danlos syndrome, a connective tissue condition. Blue sclera syndrome (Lobstein-Van der Hoeve syndrome), an advanced version of OI. Incontentia pigmenti, a genetic disorder that affects many body systems, including your eyes. Brittle cornea syndrome, a tissue disorder that makes your cornea thin. Other potential causes of a blue tint in your sclera include: Iron deficiency and iron-deficiency anemia. A lack of iron may cause a low red blood cell count. Rheumatoid arthritis, an autoimmune condition that affects your joints. Myasthenia gravis, a condition that can involve weak muscles. Some types of medications, including steroids, amiodarone and minocycline. Excessive exposure to silver. Nevus of Ota, or ocular dermal melanosis, which refers to hyperpigmentation (excessive color) of tissues. A complication of laser surgery for glaucoma.