Usually, your nerves send messages (or electrical signals) between your brain and your skin, muscles, and organs. Allodynia happens when the nervous system doesn’t work like it should. There’s a problem with how the nerves send and receive messages. Many injuries and conditions can cause issues with this communication network, including: Diabetes: Diabetes-related neuropathy happens when nerves become damaged and don’t work properly. Disorders and conditions: Many health conditions and disorders can lead to allodynia, including trigeminal neuralgia (TN), complex regional pain syndrome (CRPS), amplified musculoskeletal pain syndrome (AMPS), multiple sclerosis (MS) and fibromyalgia. Fibromyalgia: This condition causes fatigue, memory problems and pain all over the body. Medications: Some opioids can make you more sensitive to pain. Providers call this condition opioid-induced hyperalgesia. Chemotherapy drugs for cancer treatments can also lead to allodynia. Migraine headaches: Migraines occur along with allodynia up to 70% of the time. Nutritional deficiencies and diet: A severe lack of vitamin D or vitamin B can lead to allodynia. Drinking too much alcohol can cause nerve damage. Shingles: Allodynia can linger for months or years after a shingles rash has disappeared. Providers call this type of pain post herpetic neuralgia. Trauma: Some people get allodynia after an injury to the nerves (such as a deep cut). Nerve damage can also come from an amputation or radiation therapy. Trauma from a stroke can cause a heightened sensitivity to pain.