What treatment is used for Paget’s disease of the bone (osteitis deformans)? Treatments for Paget’s disease of the bone can include: Medication: Many medications can treat Paget’s disease of the bone. The most common type is bisphosphonates. The most effective bisphosphonate is zoledronate (Reclast®). Often, one dose of this drug can result in long-lasting remission of the disease but it can’t correct bone deformities. Surgery: You might need surgery to fix or improve complications of Paget’s disease of the bone. Some surgeries include knee or hip replacements, surgery to realign deformed bone and surgery to enable bone fractures to heal in a better position. Is there a cure for Paget’s disease of the bone (osteitis deformans)? There's currently no cure for Paget’s disease of the bone, but it’s treatable. The sooner Paget’s disease can be diagnosed and treated, the less likely that you’ll experience complications from the disease. How long will I have Paget’s disease of the bone (osteitis deformans)? Paget’s disease of the bone is a chronic (lifelong) condition but it’s treatable. It often gets worse slowly over time if it isn’t treated.