COPD symptoms often don't appear until significant lung damage has occurred, and they usually worsen over time, particularly if smoking exposure continues. Signs and symptoms of COPD may include: Shortness of breath, especially during physical activities Wheezing Chest tightness A chronic cough that may produce mucus (sputum) that may be clear, white, yellow or greenish Frequent respiratory infections Lack of energy Unintended weight loss (in later stages) Swelling in ankles, feet or legs